Creating Memory: Vaccines & Immunity

Episode 11: Mapping RSV evolution to infection and monoclonal antibody treatments

We talk with Dr. Cassie Simonich, Pediatric Infectious Diseases Fellow at the University of Washington, WA, who uses RSV pseudoviruses and deep mutational scanning approaches to define the evolution of the RSV fusion protein to escape natural or vaccine-induced immunity and monoclonal antibody treatments.

Episode 10: Designing a pipeline to enhance T cell-mediated vaccine protection

We talk with Dr. Alba Grifoni, Research Assistant Professor scholar in the Center for Vaccine Innovation at the La Jolla Institute for Immunology, CA, who uses bioinformatic analyses and immune focusing approaches to improve protective T cell responses induced by vaccines.

Episode 9: Using mosaic nanoparticle vaccines to generate broadly protective immmune responses

We talk with Dr. Alexander Cohen, Postdoctoral Scholar in the Division of Biology and Biological Engineering at the California Institute of Technology, CA, who uses immune focusing approaches to design vaccines that generate antibodies against conserved epitopes on viral antigens.

Episode 8: Using comparative immunology to design better vaccines

We talk with Dr. Hanover Matz, Postdoctoral Research Associate in Pathology and Immunology at Washington University School of Medicine, MO, who uses human vaccine studies as well as comparisons to other vertebrate immune systems to understand how adaptive immunity has evolved and how we can use that information to generate more effective vaccines.

Episode 7: Novel approaches to dissect antibody responses to respiratory viruses

We talk with Dr. Seth Zost, Research Instructor in the Vanderbilt Vaccine Center at Vanderbilt University Medical Center, TN, who is developing new approaches to define how antibody responses to SARS-CoV-2 and influenza viruses shape the antigenic evolution of these viruses.

Episode 6: Using phylogenetic inference to design vaccine antigens

We talk with Dr. Brett Case, Instructor of Infectious Diseases at Washington University School of Medicine, MO, who studies how to generate cross-protective and sterilizing mucosal immunity following vaccination.

Episode 5: New therapeutic strategies for treating mycobacterium tuberculosis

We talk with Dr. Christina Stallings, Professor of Molecular Microbiology at Washington University School of Medicine, MO, who studies host molecules important for mycobacterium tuberculosis pathogenesis to develop new therapies to treat mycobacterium infection and disease. 

Episode 4: From AIDS to Zika

We talk with Dr. Robert Seder, Chief of the Cellular Immunology Section of the Vaccine Research Center in Bethesda, MD, who studies how changing the route of vaccination can improve immunity and protection against pathogens.